SCN1B

Across TCGA pan-cancer cohorts, SCN1B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SCN1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SCN1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SCN1B is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

KIRC, THCA, and BLCA are the cancer types where SCN1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCN1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.799	<.001	12	view →
THCA	Male	III,IV	+2.012	<.001	11	view →
BLCA	All	IV	−1.628	<.001	10	view →
COAD	Female	II,III,IV	−0.654	<.001	9	view →
UCEC	All	III,IV	−1.674	<.001	6	view →
KICH	All	All	+1.046	.003	6	view →
LUSC	All	All	−0.451	<.001	5	view →
LUAD	All	II,III,IV	+0.627	.002	4	view →
LIHC	Female	All	+0.614	.007	4	view →
BRCA	Female	II,III,IV	−0.510	<.001	4	view →
HNSC	Male	All	−1.034	.016	3	view →
KIRP	All	All	+0.961	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SCN1B–KIRC

Open the KIRC breakdown →