SCN1B

Across TCGA patient cohorts, SCN1B mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN1B-associated genes across cancer lineages are Ku80, Src_pY416, and INPP4B. Each is linked with SCN1B in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN1B-to-partner and partner-to-SCN1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SCN1B-low versus SCN1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN1B→partner) and Y-score (partner→SCN1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.308	+3.009	.017	.019	3	1
UCEC	Src_pY416 →	-0.334	-3.143	.011	.018	3	1
UCEC	INPP4B →	-0.400	-3.156	.024	.020	2	1
UCEC	PI3K-p85 →	+0.362	+2.817	.001	.036	2	1
UCEC	Tuberin →	+0.459	+3.009	.001	.019	2	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.599	+3.169	.032	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Ku80 by SCN1B expression — UCEC

Explore this box plot interactively →