SCN1B

Across TCGA cell cohorts, SCN1B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,701 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SCN1B-associated GO terms across cancer lineages are Action potential propagation, Corticospinal tract morphogenesis, and Regulation of voltage-gated sodium channel activity. Each is linked with SCN1B in more than 12 cancer types. Because this analysis shows association rather than direction, both SCN1B-to-partner and partner-to-SCN1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Action potential propagation grouped by SCN1B-low versus SCN1B-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN1B→partner) and Y-score (partner→SCN1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Action potential propagation →	+1.107	+1.958	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Corticospinal tract morphogenesis →	+1.233	+1.785	.003	.002	3	13
LIVER	Regulation of voltage-gated sodium channel activity →	+1.264	+2.353	.004	.005	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of smoothened signaling pathway →	+0.059	+1.054	.004	.003	3	12
UPPER_AERODIGESTIVE_TRACT	Protein insertion into ER membrane →	+0.105	+1.059	<.001	.002	3	11
BONE	Positive regulation of stress fiber assembly →	+0.186	+1.499	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,701 associations by consensus.

Action potential propagation by SCN1B expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →