SCN1B

Across TCGA cell cohorts, SCN1B mutation is significantly associated with the mutation status of many other genes, with 922 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN1B-associated genes across cancer lineages are SNX10, SEPHS1, and OGFOD1. Each is linked with SCN1B in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN1B-to-partner and partner-to-SCN1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNX10 grouped by SCN1B-low versus SCN1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN1B→partner) and Y-score (partner→SCN1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SNX10 →	+5.672	+5.672	<.001	<.001	1	1
LARGE_INTESTINE	SEPHS1 →	+3.672	+4.799	.002	.002	1	1
LARGE_INTESTINE	OGFOD1 →	+3.672	+4.799	.002	.002	1	1
LARGE_INTESTINE	TFAP2C →	+3.350	+4.584	.003	.003	1	1
LARGE_INTESTINE	EDEM2 →	+2.865	+4.217	.007	.007	1	1
LARGE_INTESTINE	RHOBTB2 →	+3.087	+4.392	.005	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 922 associations by consensus.

SNX10 by SCN1B expression — LARGE_INTESTINE

Explore this box plot interactively →