SCN11A

Across TCGA patient cohorts, SCN11A mutation is significantly associated with the total protein of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN11A-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and PCNA. Each is linked with SCN11A in more than 5 cancer types. Because this analysis shows association rather than direction, both SCN11A-to-partner and partner-to-SCN11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SCN11A-low versus SCN11A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN11A→partner) and Y-score (partner→SCN11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.046	+3.186	.001	.009	3	6
UCEC	eIF4E →	+0.135	+2.100	.014	.002	3	5
STAD	PCNA →	+0.411	+3.321	<.001	.009	3	4
LUAD	4E-BP1 →	+0.385	+2.334	.003	.018	2	5
LUAD	Cyclin-B1 →	+0.699	+2.321	.001	.033	3	4
STAD	FoxM1 →	+0.237	+2.000	.026	.030	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

Caspase-7-cleavedD198 by SCN11A expression — COAD

Explore this box plot interactively →