SCN11A

Across TCGA cell cohorts, SCN11A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,254 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCN11A-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with SCN11A in more than 11 cancer types. Because this analysis shows association rather than direction, both SCN11A-to-partner and partner-to-SCN11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by SCN11A-low versus SCN11A-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN11A→partner) and Y-score (partner→SCN11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.100	+0.043	<.001	.001	3	12
STOMACH	Negative regulation of myoblast fusion →	+0.156	+0.080	<.001	<.001	3	12
STOMACH	Regulation of syncytium formation by plasma membrane fusion →	+0.129	+0.060	<.001	.001	3	9
STOMACH	Cytoplasmic translation →	+0.107	+0.059	<.001	.001	3	9
LUNG_SCLC	Regulation of myoblast fusion →	+0.093	+0.311	<.001	.002	2	10
STOMACH	Regulation of mRNA splicing, via spliceosome →	+0.095	+0.050	<.001	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,254 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by SCN11A expression — STOMACH

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