Across TCGA patient cohorts, SCN10A RNA expression is significantly associated with the go_rna of many other GO terms, with 6,720 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SCN10A-associated GO terms across cancer lineages are Respiratory system development, Regulation of small GTPase mediated signal transduction, and Amyloid-beta clearance. Each is linked with SCN10A in more than 14 cancer types. Because this analysis shows association rather than direction, both SCN10A-to-partner and partner-to-SCN10A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN10A→partner) and Y-score (partner→SCN10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Respiratory system development →	+0.051	+0.065	<.001	<.001	3	15
ESCA	Regulation of small GTPase mediated signal transduction →	+0.079	+0.073	<.001	.003	3	15
STAD	Amyloid-beta clearance →	+0.060	+0.062	<.001	<.001	3	14
STAD	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction →	+0.052	+0.065	<.001	<.001	3	14
STAD	Regulation of mononuclear cell migration →	+0.063	+0.068	<.001	<.001	3	14
STAD	Regulation of lymphocyte migration →	+0.063	+0.065	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,720 associations by consensus.

Exploration

SCN10A survival (RNA) · tumor vs normal (RNA) · all SCN10A data types