Across TCGA patient cohorts, SCN10A mutation is significantly associated with the total protein of many other genes, with 119 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN10A-associated genes across cancer lineages are Cyclin-B1, Cyclin-E2, and Caspase-7-cleavedD198. Each is linked with SCN10A in more than 5 cancer types. Because this analysis shows association rather than direction, both SCN10A-to-partner and partner-to-SCN10A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN10A→partner) and Y-score (partner→SCN10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.715	+2.078	<.001	<.001	3	6
BRCA	Cyclin-E2 →	+0.313	+2.006	<.001	.019	3	6
COAD	Caspase-7-cleavedD198 →	+1.179	+3.459	<.001	.005	3	5
BRCA	INPP4B →	-0.617	-2.700	.009	.006	3	5
SKCM	CD31 →	-0.109	-1.398	<.001	<.001	3	5
LUSC	Rad50 →	-0.113	-1.846	.010	.049	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 119 associations by consensus.

Exploration

SCN10A survival (RNA) · tumor vs normal (RNA) · all SCN10A data types