Across TCGA cell cohorts, SCN10A RNA expression is significantly associated with the mutation status of many other genes, with 156 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SCN10A-associated genes across cancer lineages are PSME4, ARAP3, and SPTBN5. Each is linked with SCN10A in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN10A-to-partner and partner-to-SCN10A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN10A→partner) and Y-score (partner→SCN10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PSME4 →	+5.000	+0.053	.005	<.001	3	2
CNS	ARAP3 →	+4.044	+0.129	.003	<.001	3	2
CNS	SPTBN5 →	+2.652	+0.067	.004	<.001	3	2
LUNG_NSCLC_LUAD	OGFRL1 →	+4.662	+0.005	<.001	<.001	3	2
LUNG_NSCLC_LUAD	CMYA5 →	+3.247	+0.002	.002	<.001	3	2
LUNG_NSCLC_LUAD	ERV3-1 →	+4.662	+0.004	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 156 associations by consensus.

Exploration

SCN10A survival (RNA) · tumor vs normal (RNA) · all SCN10A data types