Across TCGA cell cohorts, SCN10A mutation is significantly associated with the RNA expression of many other genes, with 483 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN10A-associated genes across cancer lineages are OR1N1, OR6C70, and SOX4. Each is linked with SCN10A in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN10A-to-partner and partner-to-SCN10A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN10A→partner) and Y-score (partner→SCN10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR1N1 →	+0.024	+4.369	<.001	.008	3	2
SKIN	OR6C70 →	+0.022	+1.706	.003	.004	3	2
BLOOD_Leukemia	SOX4 →	+1.565	+2.730	.006	.001	3	2
BLOOD_Leukemia	BUD13 →	+0.506	+3.459	.001	.002	3	2
BLOOD_Leukemia	PWWP3A →	+0.600	+3.228	.006	.004	3	2
BLOOD_Leukemia	YEATS2 →	+0.577	+2.730	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 483 associations by consensus.

Exploration

SCN10A survival (RNA) · tumor vs normal (RNA) · all SCN10A data types