SCML1

Across TCGA patient cohorts, SCML1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCML1-associated genes across cancer lineages are MAPK_pT202_Y204, PRDX1, and Src_pY416. Each is linked with SCML1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCML1-to-partner and partner-to-SCML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by SCML1-low versus SCML1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCML1→partner) and Y-score (partner→SCML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.484	-3.169	.022	.019	3	2
UCEC	PRDX1 →	+0.277	+3.169	.002	.019	3	2
UCEC	Src_pY416 →	-0.227	-1.986	.037	.032	3	2
UCEC	CD20 →	+0.120	+3.020	.043	.019	3	2
UCEC	EGFR_pY1068 →	-0.265	-3.459	.019	.005	3	1
UCEC	eIF4E →	+0.197	+2.321	.038	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MAPK_pT202_Y204 by SCML1 expression — UCEC

Explore this box plot interactively →