SCLY

Across TCGA patient cohorts, SCLY RNA expression is significantly associated with the protein abundance of many other proteins, with 15,208 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SCLY-associated proteins across cancer lineages are ZKSCAN8_S193, LUC7L3, and PDLIM1. Each is linked with SCLY in more than 4 cancer types. Because this analysis shows association rather than direction, both SCLY-to-partner and partner-to-SCLY results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCLY versus ZKSCAN8_S193 in HNSC, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SCLY→partner) and Y-score (partner→SCLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZKSCAN8_S193 →	+0.799	+0.715	<.001	<.001	3	5
GBM	LUC7L3 →	+0.256	+0.272	<.001	<.001	3	5
UCEC	PDLIM1 →	-0.383	-0.493	.002	<.001	3	5
LSCC	WDR75 →	+0.267	+0.323	<.001	<.001	3	5
GBM	DHX9 →	+0.236	+0.353	<.001	<.001	3	5
LSCC	POLR2B →	+0.187	+0.257	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,208 associations by consensus.

SCLY vs ZKSCAN8_S193 — HNSC

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