SCLY

Across TCGA pan-cancer cohorts, SCLY RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of SCLY’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SCLY RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SCLY is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, HNSC, and STAD are the cancer types where SCLY tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCLY RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+0.876	<.001	11	view →
HNSC	Male	IV	+0.466	<.001	11	view →
STAD	All	II,III,IV	+0.557	<.001	10	view →
LUAD	Male	II,III,IV	+0.439	<.001	9	view →
BLCA	Female	All	+0.473	<.001	8	view →
LUSC	Male	II,III,IV	+0.385	<.001	8	view →
READ	All	All	+0.650	<.001	7	view →
LIHC	All	II,III,IV	+0.434	<.001	7	view →
KICH	Female	II,III,IV	−0.472	<.001	6	view →
UCEC	All	All	+0.382	<.001	6	view →
KIRP	Male	II,III,IV	+0.365	.007	5	view →
KIRC	All	All	+0.137	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

SCLY–COAD

Open the COAD breakdown →