SCLY

Across TCGA patient cohorts, SCLY mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCLY-associated genes across cancer lineages are ERK2, MEK1, and N-Ras. Each is linked with SCLY in more than 1 cancer types. Because this analysis shows association rather than direction, both SCLY-to-partner and partner-to-SCLY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SCLY-low versus SCLY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCLY→partner) and Y-score (partner→SCLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.183	+3.169	.013	.018	3	2
UCEC	MEK1 →	+0.410	+2.321	.003	.005	3	2
UCEC	N-Ras →	-0.156	-2.558	<.001	.010	3	2
UCEC	Tuberin_pT1462 →	+0.255	+1.678	.004	.023	3	2
UCEC	ATM →	-0.422	-2.321	.015	.034	3	2
UCEC	14-3-3_beta →	-0.140	-2.558	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ERK2 by SCLY expression — UCEC

Explore this box plot interactively →