SCLY

Across TCGA cell cohorts, SCLY RNA expression is significantly associated with the go_rna of many other GO terms, with 5,284 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SCLY-associated GO terms across cancer lineages are IMP biosynthetic process, Mitochondrial large ribosomal subunit assembly, and Ribosomal large subunit assembly. Each is linked with SCLY in more than 17 cancer types. Because this analysis shows association rather than direction, both SCLY-to-partner and partner-to-SCLY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IMP biosynthetic process grouped by SCLY-low versus SCLY-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCLY→partner) and Y-score (partner→SCLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IMP biosynthetic process →	+0.147	+0.951	.001	.001	3	18
BONE	Mitochondrial large ribosomal subunit assembly →	+0.114	+0.965	<.001	<.001	3	16
BONE	Ribosomal large subunit assembly →	+0.192	+1.509	<.001	<.001	3	16
PANCREAS	XMP metabolic process →	+0.185	+1.199	<.001	<.001	3	16
PANCREAS	XMP biosynthetic process →	+0.185	+1.199	<.001	<.001	3	16
PANCREAS	'de novo' XMP biosynthetic process →	+0.185	+1.199	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,284 associations by consensus.

IMP biosynthetic process by SCLY expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →