SCLY

Across TCGA cell cohorts, SCLY protein abundance is significantly associated with the RNA expression of many other genes, with 3,646 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SCLY-associated genes across cancer lineages are ATP1A1, KLF5, and CYP39A1. Each is linked with SCLY in more than 9 cancer types. Because this analysis shows association rather than direction, both SCLY-to-partner and partner-to-SCLY results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCLY versus ATP1A1 in LIVER, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCLY→partner) and Y-score (partner→SCLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ATP1A1 →	+1.242	+1.737	.005	.005	3	10
BREAST	KLF5 →	+1.540	+0.968	<.001	.001	3	6
PANCREAS	CYP39A1 →	+1.291	+1.935	.004	<.001	3	5
PANCREAS	FNDC3B →	+1.581	+1.664	.004	.009	3	5
SOFT_TISSUE	CEP89 →	-0.771	-2.396	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	CIART →	-1.929	-1.022	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,646 associations by consensus.

SCLY vs ATP1A1 — LIVER

Explore this scatter interactively →