SCLY

Across TCGA cell cohorts, SCLY protein abundance is significantly associated with the go_rna of many other GO terms, with 2,254 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SCLY-associated GO terms across cancer lineages are Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity, Nuclear receptor-mediated steroid hormone signaling pathway, and Steroid hormone receptor signaling pathway. Each is linked with SCLY in more than 4 cancer types. Because this analysis shows association rather than direction, both SCLY-to-partner and partner-to-SCLY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity grouped by SCLY-low versus SCLY-high in BLOOD_Lymphoma.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCLY→partner) and Y-score (partner→SCLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity →	+0.202	+1.062	.001	.001	3	5
LUNG_SCLC	Nuclear receptor-mediated steroid hormone signaling pathway →	+0.102	+1.509	<.001	.001	3	5
LUNG_SCLC	Steroid hormone receptor signaling pathway →	+0.102	+1.509	<.001	.001	3	5
BREAST	Leukotriene catabolic process →	+1.076	+1.130	<.001	<.001	3	5
BREAST	Cellular response to endothelin →	+0.096	+0.901	.005	.002	3	5
BREAST	T cell mediated cytotoxicity →	+0.144	+1.123	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,254 associations by consensus.

Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity by SCLY expression — BLOOD_Lymphoma

Explore this box plot interactively →