SCLY

Across TCGA cell cohorts, SCLY mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCLY-associated genes across cancer lineages are STOML3, LCN1, and FAM187B. Each is linked with SCLY in more than 1 cancer types. Because this analysis shows association rather than direction, both SCLY-to-partner and partner-to-SCLY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STOML3 grouped by SCLY-low versus SCLY-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCLY→partner) and Y-score (partner→SCLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	STOML3 →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	LCN1 →	+0.091	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	FAM187B →	+0.052	+5.643	<.001	.002	3	1
BLOOD_Leukemia	ITIH6 →	+0.024	+4.754	<.001	.002	3	1
BLOOD_Leukemia	HCN4 →	+0.035	+3.855	.003	.007	3	1
LARGE_INTESTINE	TAS2R7 →	+0.011	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

STOML3 by SCLY expression — BLOOD_Lymphoma

Explore this box plot interactively →