SCGN

Across TCGA patient cohorts, SCGN protein abundance is significantly associated with the RNA expression of many other genes, with 7,587 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SCGN-associated genes across cancer lineages are SCG3, TUBB4A, and ASPA. Each is linked with SCGN in more than 2 cancer types. Because this analysis shows association rather than direction, both SCGN-to-partner and partner-to-SCGN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCGN versus SCG3 in PDAC, with a Pearson correlation of 0.88.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCGN→partner) and Y-score (partner→SCGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SCG3 →	+1.577	+1.202	<.001	<.001	3	3
CCRCC	TUBB4A →	+0.577	+0.915	<.001	.001	3	3
CCRCC	ASPA →	+1.055	+1.420	.002	<.001	3	3
BRCA	CPE →	+1.334	+1.141	<.001	<.001	3	3
PDAC	PAPPA2 →	+0.972	+0.994	<.001	<.001	3	3
BRCA	CNR1 →	+0.826	+1.341	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,587 associations by consensus.

SCGN vs SCG3 — PDAC

Explore this scatter interactively →