SCGB1D2

Across TCGA patient cohorts, SCGB1D2 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SCGB1D2-associated genes across cancer lineages are CLEC3A, HTR1E, and VGLL2. Each is linked with SCGB1D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCGB1D2-to-partner and partner-to-SCGB1D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC3A grouped by SCGB1D2-low versus SCGB1D2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCGB1D2→partner) and Y-score (partner→SCGB1D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CLEC3A →	+0.296	+4.521	<.001	<.001	3	1
SKCM	HTR1E →	+0.616	+3.533	<.001	.007	3	1
SKCM	VGLL2 →	+0.580	+4.141	<.001	.002	3	1
SKCM	OR10A4 →	+0.050	+3.408	<.001	.009	3	1
SKCM	VWC2L →	+0.212	+3.897	<.001	.004	3	1
SKCM	CYLC1 →	+0.017	+4.469	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

CLEC3A by SCGB1D2 expression — SKCM

Explore this box plot interactively →