SCGB1D2

Across TCGA pan-cancer cohorts, SCGB1D2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SCGB1D2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SCGB1D2 RNA is repressed in tumor relative to normal tissue. In most cancer types SCGB1D2 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and KICH are the cancer types where SCGB1D2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCGB1D2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.310	<.001	11	view →
THCA	All	IV	−1.305	<.001	10	view →
KICH	Male	All	−2.852	<.001	9	view →
KIRC	Male	II,III,IV	−1.727	<.001	7	view →
HNSC	All	All	−0.801	<.001	6	view →
BRCA	Female	All	−1.798	<.001	4	view →
ESCA	All	II,III,IV	−0.265	<.001	4	view →
LIHC	All	All	+0.603	.008	3	view →
KIRP	Male	All	−1.833	<.001	2	view →
READ	Female	All	−0.504	.009	2	view →
CHOL	All	All	+2.466	.026	1	view →
LUSC	All	All	+0.390	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SCGB1D2–COAD

Open the COAD breakdown →