SCGB1C2

Across TCGA pan-cancer cohorts, SCGB1C2 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated SCGB1C2 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SCGB1C2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SCGB1C2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and OV show a favorable association.

LUSC, STAD, and PAAD are the cancer types where SCGB1C2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
STAD	DFS	Tertile	All	0.492	0.656	.013	21	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
DLBC	OS	Tertile	II,III,IV	0.118	0.802	.025	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
ESCA	OS	Quartile	All	0.601	0.940	.018	9	view →
UVM	OS	Tertile	III,IV	0.136	0.874	<.001	9	view →
READ	OS	Tertile	III,IV	0.334	0.752	.024	9	view →
LIHC	DFS	Tertile	All	0.034	0.554	<.001	9	view →
SKCM	DFS	Tertile	All	0.906	0.729	.033	6	view →
OV	OS	Median	III,IV	0.712	0.646	.039	4	view →
BRCA	DFS	Tertile	IV	0.866	0.636	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

SCGB1C2–LUSC (OS)

Open the LUSC breakdown →