SCG5

Across TCGA patient cohorts, SCG5 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCG5-associated genes across cancer lineages are SPRYD7P1, RNA5SP405, and MIR1224. Each is linked with SCG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCG5-to-partner and partner-to-SCG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRYD7P1 grouped by SCG5-low versus SCG5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCG5→partner) and Y-score (partner→SCG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPRYD7P1 →	+0.153	+3.450	.001	.005	3	3
UCEC	RNA5SP405 →	+0.442	+3.997	<.001	.009	3	2
LUSC	MIR1224 →	+0.508	+6.438	<.001	.001	3	2
BLCA	RPL31P9 →	+0.268	+7.640	<.001	.009	3	1
BRCA	RNA5SP170 →	+0.599	+6.382	<.001	.001	3	1
BRCA	RNU6-1028P →	+0.940	+6.268	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

SPRYD7P1 by SCG5 expression — UCEC

Explore this box plot interactively →