SCG3

Across TCGA patient cohorts, SCG3 mutation is significantly associated with the RNA expression of many other genes, with 1,527 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCG3-associated genes across cancer lineages are PRIM1, DNAJC9, and GPN3. Each is linked with SCG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCG3-to-partner and partner-to-SCG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRIM1 grouped by SCG3-low versus SCG3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCG3→partner) and Y-score (partner→SCG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PRIM1 →	+0.596	+2.925	.003	<.001	3	3
UCEC	DNAJC9 →	+0.684	+3.592	.005	.001	3	3
UCEC	GPN3 →	+0.560	+3.343	.005	.005	3	3
UCEC	MCM8 →	+0.587	+2.721	.009	.003	3	3
UCEC	CNOT9 →	+0.390	+2.721	.009	.003	3	3
UCEC	EIF1AD →	+0.318	+2.754	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,527 associations by consensus.

PRIM1 by SCG3 expression — SKCM

Explore this box plot interactively →