SCG3

Across TCGA patient cohorts, SCG3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCG3-associated genes across cancer lineages are HER2_pY1248, TAZ, and CDK1_pY15. Each is linked with SCG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCG3-to-partner and partner-to-SCG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER2_pY1248 grouped by SCG3-low versus SCG3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCG3→partner) and Y-score (partner→SCG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER2_pY1248 →	-0.189	-2.584	.005	.011	3	1
SKCM	TAZ →	-0.245	-3.700	<.001	.001	3	1
SKCM	CDK1_pY15 →	+0.310	+2.836	.021	.030	3	1
UCEC	P-Cadherin →	-0.149	-2.990	.026	.036	3	1
UCEC	PKC-a_pS657 →	-0.444	-3.449	.012	.005	3	1
UCEC	PKC-a →	-0.444	-2.584	.018	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

HER2_pY1248 by SCG3 expression — SKCM

Explore this box plot interactively →