Across TCGA patient cohorts, SCFD2 protein abundance is significantly associated with the RNA expression of many other genes, with 8,031 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SCFD2-associated genes across cancer lineages are MCMBP, BUB3, and SMC3. Each is linked with SCFD2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SCFD2-to-partner and partner-to-SCFD2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCFD2→partner) and Y-score (partner→SCFD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MCMBP →	-0.520	-0.159	<.001	.001	3	5
OV	BUB3 →	-0.528	-0.424	<.001	<.001	3	4
LSCC	SMC3 →	-0.601	-0.187	<.001	<.001	3	4
UCEC	KIF20B →	-0.499	-0.118	.008	.005	3	4
LSCC	ADO →	-0.468	-0.162	.004	.003	3	4
LSCC	CHUK →	-0.460	-0.132	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,031 associations by consensus.

Exploration

SCFD2 survival (RNA) · tumor vs normal (RNA) · all SCFD2 data types