SCFD1

Across TCGA patient cohorts, SCFD1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCFD1-associated genes across cancer lineages are Cyclin-B1, p70-S6K, and PCNA. Each is linked with SCFD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCFD1-to-partner and partner-to-SCFD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SCFD1-low versus SCFD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCFD1→partner) and Y-score (partner→SCFD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.701	+2.321	<.001	<.001	3	3
UCEC	p70-S6K →	+0.138	+1.486	.027	.007	3	2
UCEC	PCNA →	+0.165	+1.847	.018	.007	3	2
UCEC	Tuberin →	+0.340	+2.087	<.001	.004	3	2
UCEC	ASNS →	+0.302	+1.807	.010	.024	3	2
UCEC	ATM →	-0.297	-1.861	.043	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Cyclin-B1 by SCFD1 expression — UCEC

Explore this box plot interactively →