SCFD1

Across TCGA pan-cancer cohorts, SCFD1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SCFD1 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SCFD1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCFD1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

ACC, UVM, and KIRC are the cancer types where SCFD1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.286	0.617	<.001	81	view →
UVM	DFS	Quartile	III,IV	0.170	0.832	<.001	54	view →
KIRC	OS	Median	All	0.696	0.566	<.001	44	view →
LIHC	OS	Median	II,III,IV	0.570	0.795	.001	42	view →
KICH	DFS	Tertile	III,IV	0.193	1.000	.003	31	view →
BLCA	OS	Tertile	All	0.655	0.754	.012	29	view →
STAD	DFS	Median	All	0.342	0.616	.013	24	view →
CESC	OS	Quartile	III,IV	0.167	0.608	.008	22	view →
SKCM	OS	Quartile	All	0.386	0.203	<.001	20	view →
LUSC	DFS	Median	III,IV	0.522	0.770	<.001	18	view →
HNSC	OS	Median	III,IV	0.182	0.394	.009	16	view →
UCS	DFS	Tertile	IV	0.996	0.482	.036	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SCFD1–ACC (DFS)

Open the ACC breakdown →