SCD5

Across TCGA patient cohorts, SCD5 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCD5-associated genes across cancer lineages are Src_pY527, FoxM1, and p62 Lck ligand. Each is linked with SCD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCD5-to-partner and partner-to-SCD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by SCD5-low versus SCD5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCD5→partner) and Y-score (partner→SCD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Src_pY527 →	-0.503	-3.000	.039	.036	3	2
UCEC	FoxM1 →	+0.251	+2.817	.045	.036	3	2
UCEC	p62 Lck ligand →	+0.425	+3.331	.006	.005	3	2
UCEC	4E-BP1 →	+0.433	+3.029	<.001	.018	3	2
UCEC	EGFR_pY1068 →	-0.277	-2.459	.022	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.230	-3.000	.004	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Src_pY527 by SCD5 expression — SKCM

Explore this box plot interactively →