SCD5

Across TCGA pan-cancer cohorts, SCD5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SCD5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SCD5 RNA is repressed in tumor relative to normal tissue. In most cancer types SCD5 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and HNSC are the cancer types where SCD5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCD5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−2.430	<.001	12	view →
KICH	Male	III,IV	−4.802	<.001	11	view →
HNSC	Male	III,IV	+2.310	<.001	11	view →
LUAD	Female	III,IV	−2.118	<.001	9	view →
KIRP	Male	All	−2.492	<.001	7	view →
CHOL	All	All	+2.868	<.001	3	view →
LUSC	All	All	−0.441	.023	3	view →
READ	Female	All	−1.738	.007	2	view →
BLCA	All	IV	−1.188	.030	2	view →
LIHC	Male	All	−0.644	<.001	2	view →
PRAD	All	All	−0.627	<.001	2	view →
BRCA	Female	All	−0.368	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SCD5–KIRC

Open the KIRC breakdown →