SCD

Across TCGA patient cohorts, SCD mutation is significantly associated with the RNA expression of many other genes, with 3,934 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCD-associated genes across cancer lineages are RNA5SP176, PHBP6, and RNU6-1019P. Each is linked with SCD in more than 1 cancer types. Because this analysis shows association rather than direction, both SCD-to-partner and partner-to-SCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP176 grouped by SCD-low versus SCD-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCD→partner) and Y-score (partner→SCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP176 →	+0.323	+7.954	<.001	.008	3	2
HNSC	PHBP6 →	+0.054	+7.954	<.001	.008	3	2
SKCM	RNU6-1019P →	+0.512	+4.265	<.001	.003	3	2
UCEC	RNA5SP113 →	+0.381	+2.702	<.001	.003	3	2
UCEC	BNIP3P41 →	+0.009	+3.834	<.001	.007	3	2
UCEC	PRAL →	-0.135	-2.712	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,934 associations by consensus.

RNA5SP176 by SCD expression — HNSC

Explore this box plot interactively →