SCARB2

Across TCGA patient cohorts, SCARB2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,052 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SCARB2-associated genes across cancer lineages are MANBA, VRK1, and TOPBP1. Each is linked with SCARB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SCARB2-to-partner and partner-to-SCARB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCARB2 versus MANBA in OV, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCARB2→partner) and Y-score (partner→SCARB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MANBA →	+0.521	+0.354	<.001	.008	3	5
LSCC	VRK1 →	-0.757	-0.340	.001	<.001	3	5
LSCC	TOPBP1 →	-0.671	-0.304	<.001	<.001	3	5
BRCA	OLFML3 →	+0.930	+0.366	<.001	.005	3	4
LSCC	CTSD →	+0.638	+0.355	<.001	<.001	3	4
LSCC	ACYP1 →	-0.576	-0.354	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,052 associations by consensus.

SCARB2 vs MANBA — OV

Explore this scatter interactively →