SCARB2

Across TCGA patient cohorts, SCARB2 mutation is significantly associated with the RNA expression of many other genes, with 1,059 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCARB2-associated genes across cancer lineages are RNU6-844P, RNA5-8SN2, and RNA5SP534. Each is linked with SCARB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCARB2-to-partner and partner-to-SCARB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-844P grouped by SCARB2-low versus SCARB2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCARB2→partner) and Y-score (partner→SCARB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-844P →	+0.579	+3.926	<.001	.005	3	3
BRCA	RNA5-8SN2 →	+0.220	+5.950	<.001	.001	3	2
BRCA	RNA5SP534 →	+0.603	+5.639	<.001	.002	3	2
UCEC	RN7SL248P →	+0.053	+2.985	<.001	.006	3	2
UCEC	RNVU1-28 →	+0.548	+1.760	<.001	.004	3	2
HNSC	MIR663B →	+0.602	+5.435	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,059 associations by consensus.

RNU6-844P by SCARB2 expression — BLCA

Explore this box plot interactively →