SCARA3

Across TCGA patient cohorts, SCARA3 mutation is significantly associated with the RNA expression of many other genes, with 2,159 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCARA3-associated genes across cancer lineages are BUB3, CDC45, and PSMC3IP. Each is linked with SCARA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCARA3-to-partner and partner-to-SCARA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by SCARA3-low versus SCARA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCARA3→partner) and Y-score (partner→SCARA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.419	+2.775	.001	.002	3	3
UCEC	CDC45 →	+0.630	+3.923	.002	<.001	3	3
UCEC	PSMC3IP →	+0.568	+2.403	<.001	<.001	3	3
BLCA	RNA5SP129 →	+0.356	+3.343	.001	.007	3	3
COAD	ZNF460 →	+0.598	+3.200	.007	.009	3	2
COAD	TRBJ2-2P →	+1.104	+3.422	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,159 associations by consensus.

BUB3 by SCARA3 expression — UCEC

Explore this box plot interactively →