SCAP

Across TCGA cell cohorts, SCAP mutation is significantly associated with the mutation status of many other genes, with 6,509 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCAP-associated genes across cancer lineages are COL12A1, DNAH1, and KCNQ5. Each is linked with SCAP in more than 4 cancer types. Because this analysis shows association rather than direction, both SCAP-to-partner and partner-to-SCAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL12A1 grouped by SCAP-low versus SCAP-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAP→partner) and Y-score (partner→SCAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	COL12A1 →	+5.115	+5.115	.005	.005	1	5
OVARY	DNAH1 →	+2.824	+4.347	.001	.001	1	5
STOMACH	KCNQ5 →	+4.942	+4.942	.001	.001	1	5
LUNG_SCLC	ZMYND8 →	+5.502	+5.502	.003	.003	1	5
BLOOD_Lymphoma	ADGRA2 →	+3.316	+3.316	.006	.006	1	5
SKIN	ARID1B →	+3.169	+4.548	.004	.004	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,509 associations by consensus.

COL12A1 by SCAP expression — PANCREAS

Explore this box plot interactively →