SCAI

Across TCGA pan-cancer cohorts, SCAI Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SCAI data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SCAI Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SCAI expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BLCA, CESC, and OV are the cancer types where SCAI Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.164	0.692	<.001	21	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	12	view →
OV	OS	Median	IV	0.007	0.760	<.001	12	view →
UCEC	DFS	Median	All	1.000	0.829	.018	8	view →
PRAD	DFS	Median	All	0.617	0.886	.011	6	view →
SKCM	DFS	Median	All	0.416	0.622	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SCAI–BLCA (OS)

Open the BLCA breakdown →