SCAI

Across TCGA pan-cancer cohorts, SCAI mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SCAI data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SCAI mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SCAI expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and GBM are the cancer types where SCAI mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.866	0.489	.002	25	view →
HNSC	DFS	Median	All	0.989	0.914	.012	4	view →
GBM	DFS	Quartile	All	0.861	0.637	.029	1	view →
CCRCC	OS	Median	All	0.914	0.785	.036	1	view →
PDAC	OS	Tertile	All	0.636	0.380	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SCAI–LSCC (DFS)

Open the LSCC breakdown →