SCAI

Across TCGA patient cohorts, SCAI mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCAI-associated genes across cancer lineages are PDCD4, ATM, and c-Met_pY1235. Each is linked with SCAI in more than 1 cancer types. Because this analysis shows association rather than direction, both SCAI-to-partner and partner-to-SCAI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SCAI-low versus SCAI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAI→partner) and Y-score (partner→SCAI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.438	-2.459	.011	.018	3	2
UCEC	ATM →	-0.620	-2.247	<.001	.001	3	2
UCEC	c-Met_pY1235 →	+0.058	+1.502	.033	.030	3	2
UCEC	14-3-3_beta →	-0.093	-2.432	.011	.018	3	1
UCEC	EGFR_pY1068 →	-0.310	-2.247	<.001	.001	3	1
UCEC	eIF4E →	+0.194	+2.736	.012	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PDCD4 by SCAI expression — UCEC

Explore this box plot interactively →