SCAI

Across TCGA cell cohorts, SCAI RNA expression is significantly associated with the go_rna of many other GO terms, with 5,027 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCAI-associated GO terms across cancer lineages are Post-transcriptional gene silencing, Epigenetic regulation of gene expression, and mRNA transport. Each is linked with SCAI in more than 17 cancer types. Because this analysis shows association rather than direction, both SCAI-to-partner and partner-to-SCAI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-transcriptional gene silencing grouped by SCAI-low versus SCAI-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAI→partner) and Y-score (partner→SCAI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Post-transcriptional gene silencing →	+0.133	+0.837	<.001	<.001	3	17
BONE	Epigenetic regulation of gene expression →	+0.084	+0.798	<.001	<.001	2	18
BONE	mRNA transport →	+0.111	+0.642	<.001	<.001	3	17
BONE	mRNA export from nucleus →	+0.117	+0.657	<.001	<.001	3	17
OVARY	Heterochromatin organization →	+0.066	+0.607	<.001	.004	3	16
SOFT_TISSUE	RNA export from nucleus →	+0.126	+0.704	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,027 associations by consensus.

Post-transcriptional gene silencing by SCAI expression — STOMACH

Explore this box plot interactively →