SBNO2

Across TCGA patient cohorts, SBNO2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SBNO2-associated genes across cancer lineages are ATM, p90 RSK, and Caspase-7-cleavedD198. Each is linked with SBNO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SBNO2-to-partner and partner-to-SBNO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SBNO2-low versus SBNO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SBNO2→partner) and Y-score (partner→SBNO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.666	-2.687	<.001	.005	3	3
SKCM	p90 RSK →	+0.234	+3.321	.032	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.772	+2.604	<.001	.005	3	2
UCEC	Di-Ras3 →	-0.160	-1.678	.004	.023	3	2
SKCM	PI3K-p85 →	+0.258	+3.321	.018	.010	3	2
COAD	Akt_pT308 →	+0.397	+2.330	.006	.020	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ATM by SBNO2 expression — UCEC

Explore this box plot interactively →