Across TCGA patient cohorts, SBK2 mutation is significantly associated with the RNA expression of many other genes, with 109 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SBK2-associated genes across cancer lineages are CYCSP46, PAFAH1B2P1, and PGAM1P1. Each is linked with SBK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SBK2-to-partner and partner-to-SBK2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SBK2→partner) and Y-score (partner→SBK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CYCSP46 →	+0.358	+3.496	<.001	.008	3	2
COAD	PAFAH1B2P1 →	+0.168	+3.596	.004	.004	3	2
COAD	PGAM1P1 →	+0.135	+4.893	<.001	<.001	3	2
COAD	PANDAR →	+0.103	+4.864	<.001	<.001	3	2
HNSC	DRD5P2 →	+0.016	+4.578	<.001	.008	3	1
HNSC	RNU6-621P →	+0.514	+4.780	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 109 associations by consensus.

Exploration

SBK2 survival (RNA) · tumor vs normal (RNA) · all SBK2 data types