Across TCGA pan-cancer cohorts, SBK2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SBK2’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where SBK2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SBK2 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

BRCA, KIRP, and KICH are the cancer types where SBK2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SBK2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	+0.284	<.001	6	view →
KIRP	All	All	+0.247	.028	2	view →
KICH	All	IV	+0.512	.046	1	view →
HNSC	All	All	−0.475	.035	1	view →
CHOL	All	All	+0.153	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SBK2 RNA expression & survival · all SBK2 data types