SBF2

Across TCGA pan-cancer cohorts, SBF2 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated SBF2 data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SBF2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SBF2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, BLCA, and KIRC are the cancer types where SBF2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.936	0.598	<.001	36	view →
BLCA	DFS	Median	II,III,IV	0.860	0.601	.005	26	view →
KIRC	DFS	Median	All	0.127	0.865	<.001	14	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
PAAD	OS	Median	All	0.112	0.640	.004	12	view →
OV	OS	Median	II,III,IV	0.358	0.692	.015	12	view →
READ	OS	Median	II,III,IV	0.187	0.653	.030	9	view →
LIHC	DFS	Median	All	0.119	0.559	<.001	9	view →
PRAD	DFS	Median	All	0.670	0.935	.001	6	view →
LUAD	OS	Median	All	0.128	0.364	.039	4	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
STAD	DFS	Median	All	0.211	0.709	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

SBF2–UCEC (DFS)

Open the UCEC breakdown →