SBF2

Across TCGA patient cohorts, SBF2 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SBF2-associated genes across cancer lineages are JNK_pT183_Y185, PCNA, and ATM. Each is linked with SBF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SBF2-to-partner and partner-to-SBF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SBF2-low versus SBF2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SBF2→partner) and Y-score (partner→SBF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	JNK_pT183_Y185 →	-0.307	-3.169	.012	.018	3	3
COAD	PCNA →	+0.244	+3.330	.036	.005	3	3
COAD	ATM →	-0.586	-3.000	.001	.034	3	3
COAD	Caspase-7-cleavedD198 →	+1.497	+2.824	<.001	.034	3	3
UCEC	MEK1 →	+0.265	+1.906	.004	<.001	3	3
UCEC	PDCD4 →	-0.389	-1.736	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

JNK_pT183_Y185 by SBF2 expression — COAD

Explore this box plot interactively →