SBDS

Across TCGA patient cohorts, SBDS mutation is significantly associated with the RNA expression of many other genes, with 303 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SBDS-associated genes across cancer lineages are RNU6-1065P, OR7E162P, and CTDSPL2P1. Each is linked with SBDS in more than 1 cancer types. Because this analysis shows association rather than direction, both SBDS-to-partner and partner-to-SBDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1065P grouped by SBDS-low versus SBDS-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SBDS→partner) and Y-score (partner→SBDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1065P →	+0.430	+3.913	<.001	.006	3	2
CESC	OR7E162P →	+0.072	+4.455	<.001	.005	3	2
CESC	CTDSPL2P1 →	+0.026	+4.812	<.001	.006	3	2
CESC	CHCHD2P7 →	+0.167	+4.601	<.001	.004	3	2
CESC	CACNA1C-IT1 →	+0.056	+5.569	<.001	.002	3	2
CESC	RPL37P10 →	+0.151	+4.193	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 303 associations by consensus.

RNU6-1065P by SBDS expression — SKCM

Explore this box plot interactively →