SASS6

Across TCGA patient cohorts, SASS6 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SASS6-associated genes across cancer lineages are EGFR, eIF4G, and EGFR_pY1068. Each is linked with SASS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SASS6-to-partner and partner-to-SASS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by SASS6-low versus SASS6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SASS6→partner) and Y-score (partner→SASS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.309	-3.906	<.001	<.001	3	2
UCEC	eIF4G →	+0.298	+2.807	.027	.003	3	2
UCEC	EGFR_pY1068 →	-0.260	-3.321	.017	.009	3	1
UCEC	eIF4E →	+0.217	+3.183	.018	.009	3	1
UCEC	A-Raf_pS299 →	-0.136	-2.321	.009	.034	3	1
UCEC	ERK2 →	+0.244	+3.321	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EGFR by SASS6 expression — UCEC

Explore this box plot interactively →