SASS6

Across TCGA cell cohorts, SASS6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,924 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SASS6-associated GO terms across cancer lineages are DNA replication, DNA-templated DNA replication, and Regulation of centriole replication. Each is linked with SASS6 in more than 19 cancer types. Because this analysis shows association rather than direction, both SASS6-to-partner and partner-to-SASS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication grouped by SASS6-low versus SASS6-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SASS6→partner) and Y-score (partner→SASS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA replication →	+0.127	+1.448	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.150	+1.448	<.001	<.001	3	20
BLOOD_Myeloma	Regulation of centriole replication →	+0.093	+1.500	<.001	<.001	3	20
OESOPHAGUS	Positive regulation of centriole replication →	+0.113	+1.136	<.001	<.001	3	20
PANCREAS	Negative regulation of G2/M transition of mitotic cell cycle →	+0.083	+0.970	<.001	<.001	3	19
PANCREAS	Negative regulation of cell cycle G2/M phase transition →	+0.082	+0.949	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,924 associations by consensus.

DNA replication by SASS6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →