SASS6

Across TCGA cell cohorts, SASS6 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SASS6-associated genes across cancer lineages are FMO1, GRM6, and MSGN1. Each is linked with SASS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SASS6-to-partner and partner-to-SASS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FMO1 grouped by SASS6-low versus SASS6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SASS6→partner) and Y-score (partner→SASS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FMO1 →	+0.096	+3.658	.004	.005	3	1
LARGE_INTESTINE	GRM6 →	+0.085	+4.115	<.001	.001	3	1
LARGE_INTESTINE	MSGN1 →	+0.080	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	XKR3 →	+0.030	+4.115	.006	.001	3	1
LARGE_INTESTINE	OR11H4 →	+0.146	+3.878	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

FMO1 by SASS6 expression — LARGE_INTESTINE

Explore this box plot interactively →