SASH3

Across TCGA patient cohorts, SASH3 mutation is significantly associated with the RNA expression of many other genes, with 3,260 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SASH3-associated genes across cancer lineages are SNORD114-28, RPL6P29, and MIR5582. Each is linked with SASH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SASH3-to-partner and partner-to-SASH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD114-28 grouped by SASH3-low versus SASH3-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SASH3→partner) and Y-score (partner→SASH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	SNORD114-28 →	+0.323	+7.962	<.001	.007	3	2
SKCM	RPL6P29 →	+0.112	+4.328	<.001	<.001	3	2
CESC	MIR5582 →	+0.755	+3.744	<.001	.004	3	2
CESC	SPCS2P2 →	+0.036	+4.247	<.001	.007	3	2
CESC	PAX3 →	+0.671	+3.862	<.001	.002	3	2
UCEC	ZNHIT3 →	+0.426	+2.223	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,260 associations by consensus.

SNORD114-28 by SASH3 expression — THCA

Explore this box plot interactively →