SASH3

Across TCGA cell cohorts, SASH3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SASH3-associated genes across cancer lineages are PAGE3, OR10J5, and CCER1. Each is linked with SASH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SASH3-to-partner and partner-to-SASH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAGE3 grouped by SASH3-low versus SASH3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SASH3→partner) and Y-score (partner→SASH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PAGE3 →	+0.020	+4.222	<.001	.006	3	2
SKIN	OR10J5 →	+0.026	+6.022	<.001	.001	3	1
SKIN	CCER1 →	+0.063	+6.022	<.001	.001	3	1
SKIN	NPS →	+0.441	+5.415	<.001	.004	3	1
SKIN	KIR2DS4 →	+0.006	+5.415	.007	.004	3	1
SKIN	OR8B4 →	+0.032	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PAGE3 by SASH3 expression — OVARY

Explore this box plot interactively →